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Publication Type
Conference Proceedings
Author, Analytic
Townsend, Norman; Jackson, Yvette
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Paper/Section Title
Synthesis of pyridoacridine analogues- in search of the elusive drug
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Proceedings Title
Annual National Conference on Science and Technology: Science and Technology for Economic Growth and Development: Proceedings of the Seventeenth Annual National Conference on Science and Technology
Date of Meeting
November 19-22, 2003
Place of Meeting
Kingston, Jamaica
Place of Publication
Kingston, Jamaica
Publisher Name
The Scientific Research Council
Date of Publication
2003
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Abstract
Pyridoacridines such as the dercitin alkaloids, kuanoniamines A, B and D and shermilamine A-C have been found possess high antiviral, antibacterial and antitumor activity. They, however, are quite toxic to normal mammalian cells. A compound that possesses all the biological activities and none of the toxicity would therefore be a dream drug.An analogue of kuanoniamine A, 1 is possibly such a compound. Synthesis of this novel compound, achieved in 11% yield from readily available dimethoxyaniline, will be discussed. This synthetic pathway also yielded novel intermediates possessing the ability to regulate the release of calcium in the body. The biological properties of the kuanoniamines and their intermediates will also be discussed.....
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