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Publication Type
Journal Article
Author, Analytic
Russell, K. R. ; Omoruyi, Felix. O. ; Pascoe, K. O. ; Morrison, E. Y.
Author Affiliation, Ana.
n/a
Article Title
Hypoglycaemic activity of Bixa orellana extract in the dog
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Methods Find Exp Clin Pharmacol
Translated Title
n/a
Reprint Status
n/a
Date of Publication
2008 May
Volume ID
30
Issue ID
4
Page(s)
301-5
Language
eng
Connective Phrase
n/a
Location/URL
ISSN
0379-0355 (Print)
Notes
n/a
Abstract
In West Indian folklore, a variety of plants are used for medicinal purposes. One such plant, Bixa orellana (annatto), is commonly used in the treatment of diabetes mellitus. Preliminary studies have shown that a crude annatto seed extract exhibited either glucose lowering or hyperglycaemia-inducing activity depending on how it was further manipulated. This present investigation sought to determine the effects of the glucose-lowering extract on C-peptide and streptozotocin-induced diabetic dogs. This annatto extract was found to decrease blood glucose levels in fasting normoglycaemic and streptozotocin-induced diabetic dogs. In addition, in normal dogs, it suppressed the postprandial rise in blood glucose after an oral glucose load. Interestingly, the extract also caused an increase in insulin-to-glucose ratio in normal dogs. Increased insulin levels were not due to increased insulin synthesis as after 1-h residence time and half-hour postprandial, decreased C-peptide levels was observed. It was concluded that Bixa orellana (annatto) lowered blood glucose by stimulating peripheral utilization of glucose, and it is possible that this glucose-lowering extract might be of pharmacological importance.....
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