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Publication Type
Conference Proceedings
UWI Author(s)
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Bowen-Forbes, Camille S.; Mulabagal, V.; Liu, Y.; Nair, M. G.
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Paper/Section Title
Jamaican Rubus Fruits Inhibit Lipid Peroxidation and Cyclooxygenase Enzymes Activities.
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Proceedings Title
American Chemical Society, 42nd Western Regional Conference
Date of Meeting
September 2008
Place of Meeting
Las Vegas, NV, USA.
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Date of Publication
2008
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Abstract
Jamaica is home to thousands of plant species, many of which yield edible fruits that are significantly under utilized. Rosaceae (rose family) is a diverse family of plants comprised of over 100 genera and 3000 species, among which are the producers of some of the most delicious and succulent fruits. One of such genera is Rubus, the producer of blackberries and raspberries, which are well known for their high anthocyanin contents. Three Jamaican Rubus species, namely R. jamaicensis, R. rosifolius and R. racemosus were the subjects of this study. The former is a blackberry, and the latter two are red raspberry and black raspberry, respectively. These species grow wild, and although many eat the fruits, they are not well known by the majority of the populous. We have determined the anthocyanin content, the lipid peroxidation (LPO) and cyclooxygenase (COX-1 and -2) enzyme inhibitory activities of their extracts. The hexane, ethyl acetate and methanolic extracts showed good antioxidant activity, as derived from LPO inhibitory analysis (42-84%; 50 ppm). Moderate anti-inflammatory activity was also exhibited by some of the extracts, based on their inhibition of COX-1 and -2 enzymes at 25 ppm (? 33%). The ethyl acetate extract of R. rosifolius, being the most complex of the extracts (based on TLC), and displaying good biological activity, was the focus of phytochemical investigation. Eight poly-hydroxylated ursolic acid derivatives were isolated and characterized. Their biological activities including tumor cell proliferation inhibitory activities will be explored. HPLC analysis revealed that R. jamaicensis and R. racemosus possess superior levels of anthocyanins (1673 and 1882 mg/100g FW) compared to the levels reported in the literature for most of such fruits. R. rosifolius contained 146 mg/100g FW. Our results indicate that consumption of Rubus fruits may contribute to the overall health of consumers.....
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