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Publication Type
Conference Proceedings
UWI Author(s)
Author, Analytic
Liu, Y.; Mulabagal, V.; Bowen-Forbes, Camille S.; Nair, M.G.
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Paper/Section Title
Bioactive Compounds Present in the Indian Herbal Drink Prepared by Boiling the Commercial Product Panamrutham.
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Proceedings Title
American Chemical Society, 42nd Western Regional Conference
Date of Meeting
September 2008
Place of Meeting
Las Vegas, NV, USA.
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Date of Publication
2008
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Abstract
In recent years, people have resorted to herbal drink to maintain good health and vitality. Panamrutham, a powdered mixture of dried plants Acacia catechu, Vetiveria zizanioides, Prunus cerasoides, Syzygium aromaticum, Pterocarpus santalinus, Hemidesmus indicus, Crataeva religiosa and Elettaria cardamomum, is one of the herbal mixtures sold in India. It is used for the exclusive preparation of decoction with boiled-water as an everyday drink. Anecdotal reports of this commercial product suggest that its consumption improves digestion and blood purification. Therefore, the aim of this study was to isolate the putative biomolecules present in the drink by using bioassay-guided fractionation and purification methods. The lipid peroxidation (LPO) and cyclooxygenase enzyme (COX) inhibitory activities of its boiled-water extract inhibited the COX-1 and -2 enzymes by 65.2 and 80.9 %, respectively, at 250 ppm concentration. Similarly, the LPO inhibition of the extract was 96% at 25 ppm concentration. Chromatographic purification of the extract by C-18 medium pressure liquid chromatography afforded nine compounds, including phenolics and sesquiterpenoids. These compounds will be studied for their chemical identity as well as COX-1 and -2 enzymes, LPO and tumor cell proliferation inhibitory activities. The preliminary bioassay results of the crude extract indicate that the consumption of this herbal drink may yield health benefits.....
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