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Publication Type
Journal Article
Author, Analytic
Rahbar, MH; Samms-Vaughan, Maureen; Ma, J; Bressler, J; Dickerson, AS; Hessabi, M; Loveland, KA; Grove, ML; Shakespeare-Pellington, Sydonnie; Beecher, Compton; McLaughlin, Wayne; Boerwinkle, E
Author Affiliation, Ana.
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Article Title
Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder
Medium Designator
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Connective Phrase
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Journal Title
Research in Autism Spectrum Disorders
Translated Title
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Reprint Status
Refereed
Date of Publication
2015
Volume ID
18
Issue ID
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Page(s)
73-82
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
We used data from 100 age- and sex-matched case-control pairs (age 2-8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC = 12g/L had about 4 times higher odds of ASD than those with BMC < 12g/L, (P=0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC = 12g/L had about six times higher odds of ASD than those with BMC < 12g/L, (P=0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted.....
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