Fletcher, Horace M.; Mitchell, Sharmaine Y.; Frederick, Joseph; Simeon, Donald T.; Brown, D.
Author Affiliation, Ana.
Obstetrics, Gynaecology and Child Health
Intravaginal misoprostol versus dinoprostone as cervical ripening and labor-inducing agents.
Obstetrics and Gynecology
Date of Publication
To compare dinoprostone (prostaglandin E2) and misoprostol (prostaglandin E1) for ripening the cervix and inducing labour at term, 63 women were randomized to receive 100 micrograms misoprostol or 3mg dinoprostone, both as intravaginal tablets. There was no statistical difference between the groups for pre-induction status. The mean Bishop scores before drug insertion were almost identical. Twelve hours after insertion, the mean change in the Bishop score was significantly higher in those receiving misoprostol (5.0 vs 3.3) (p=0.008). However, there was no significant difference in induction-to-delivery interval, spontaneous labour rates, types of delivery, fetal outcome, or maternal complications. Misoprostol is therefore as effective as dinoprostone for inducing labor at term.....