Wiktor, Stefan Z.; Pate, Ernest J.; Murphy, Edward L.; Palker, Thomas J.; Champagnie, Eleanor M.; Ramlal, Angela M.; Cranston, Beverley; Hanchard, Barrie; Blattner, William A.
Author Affiliation, Ana.
Obstetrics, Gynaecology and Child Health; Pathology
Mother-to-child transmission of human T-cell lymphotropic virus type I (HTLV-1) in Jamaica: Association with antibodies to envelope glycoprotein (gp46) epitopes.
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Date of Publication
To study mother-to-child transmission of HTLV-I in Jamaica, antenatal patients in Kingston, Jamaica were screened between 1983 and 1985 . Of 2,329 women, 81 (3.5%) were HTLV-I seropositive. Two to three years later, 36 seropositive mothers were contacted again, and blood was drawn from them and their children. All sera were tested for HTLV-I antibodies, and mothers' sera were additionally tested for HTLV-I whole-virus antibody titer, syncytium-inhibition neutralizing antibody titer, and titers to six synthetic peptides from the HTLV-I envelope glycoprotein gp46. Seventeen of 74 (23 %) children were seropositive (95% confidence interval (CI) 15-34%) . HTLV-I transmission was associated with breast-feeding duration of 6 months (relative risk (RR) 3.2; CI 0.4-22.1); maternal age 30 years (RR 2.8; CI 1.0 - 7.8); and higher maternal whole-virus antibody titer (RR 3.3; CI 1.3 - 8.5). After controlling for higher whole-virus antibody titer, transmission remained associated with higher titer of neutralizing antibody and higher titer of antibody to the peptide sp4al, corresponding to amino acids 196 - 209 of the gp46 envelope glycoprotein. Mother-to-child transmission of HTLV-I in Jamaica, therefore, is associated with longer duration of breast-feeding, older age, and higher HTLV-I antibody titer - in particular, to a certain immunogenic portion of the gp46 envelope glycoprotein.....