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Publication Type
Journal Article
Author, Analytic
Fox, Peter D.; Higgs, Douglas R.; Serjeant, Graham R.
Author Affiliation, Ana.
Medical Research Council Laboratories (Sickle Cell)
Article Title
Influence of alpha thalassaemia on the retinopathy of homozygous sickle cell disease.
Medium Designator
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Connective Phrase
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Journal Title
British Journal of Ophthalmology
Translated Title
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Reprint Status
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Date of Publication
1993
Volume ID
77
Issue ID
2
Page(s)
89-90
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
Homozygous alpha+ thalassaemia (alpha-/alpha-) ameliorates some of the clinical manifestations of homozygous sickle cell (SS) disease but its effect on retinal complications remains unknown. This has been assessed by visual examination and flourescein angiography in 39 subjects with SS disease and homozygous alpha+ thalassaemia and in 39 age/sex matched controls with SS disease but with a normal alpha genotype (alpha alpha/alpha alpha). The results indicate that homozygous alpha+ thalassaemia reduces the extent of peripheral retinal vessel closure but has no apparent effect on the frequency of proliferative sickle retinopathy.....
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Keywords
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