Penman, Alan D.; Talbot, John F.; Chuang, Elaine L.; Thomas, Peter W.; Serjeant, Graham R.; Bird, Alan C.
Author Affiliation, Ana.
Medical Research Council Laboratories (Sickle Cell)
New classification of peripheral retinal vascular changes in sickle cell disease.
British Journal of Ophthalmology
Date of Publication
In the Jamaica Sickle Cohort study all subjects are scheduled to receive annual ocular examination and fluorescein angiography. The results have now been analysed in subjects with SS and SC disease using a new classificaton system based on a comparison of the peripheral retinal vascular bed with that recorded in the cohort with normal haemoglobin (AA) genotype. This classification system is useful in identifying the likelihood of threat to vision in young Jamaicans with sickle cell disease, and the higher frequency of proliferative retinopathy in SC can be explained by the higher prevalence of a qualitatively abnormal peripheral retinal vasculture.....