Cooper, Richard S.; McFarlane Anderson, Norma; Bennett, Franklyn I.; Wilks, Rainford J.; Puras, Angel; Tewksbury, Duane; Ward, Ryk; Forrester, Terrence E.
Author Affiliation, Ana.
Tropical Metabolism Research Unit
ACE, angiotensinogen and obesity: A potential pathway leading to hypertension.
Journal of Human Hypertension
Date of Publication
Examines the potential relationship between the Renin-angiotensin system (RAS) and obesity. Based on community sampling, recruited 449 individuals from metropolitan Kingston, Jamaica. Serum angiotensin-converting enzyme (ACE) and circulating angiotensinogen levels were measured and the associated genes were typed for previously described polymorphisms. Obese individuals (body mass index 31) had significantly higher serum ACE and angiotensinogen levels, this relationship persisted for ACE in multivariate analyses controlling for BP, hypertension status, age and gender. The insertion/deletion polymorphism of the ACE gene was associated with variation in the levels of ACE, but inconsistently with body mass index. Variants of the angiotensinogen gene leading to amino acid substitutions at positions 174 and 235 did not influence levels either of angiotensinogen or obesity. These data suggest that obesity may alter the levels of ACE and angiotensinogen, and provide a potential pathway through which obesity leads to elevation of BP.....