Forrester, Terrence E.; McFarlane Anderson, Norma; Bennett, Franklyn I.; Wilks, Rainford J.; Cooper, Richard S.; Rotimi, Charles N.; Morrison, Linda; Ward, Ryk
Author Affiliation, Ana.
Tropical Metabolism Research Unit
The angiotensin converting enzyme and blood pressure in Jamaicans
American Journal of Hypertension
Date of Publication
5 part 1
In a population-based survey in Kingston, Jamaica, study examines the association between angiotensin converting enzyme genotype, angiotensin converting enzyme serum activity and blood pressure. Serum angiotensin converting enzyme activity was measured and genotyping performed for the I/D polymorphism in 500 community residents. The overall prevalence of the D allele was 59.3 percent. Angiotensin converting enzyme genotype was not significantly related to blood pressure (P - 16), although it did influence angiotensin-converting enzyme activity, leading to an increase of 35 percent among individuals with the DD as compared with II genotype. Angiotensin converting enzyme levels were significantly higher in hypertensives as compared with normotensives (P .05). A modest correlation was observed between blood pressure and angiotensin converting enzyme activity among untreated individuals.....