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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Duff, Edith M.; Cooper, Edward S.
Author Affiliation, Ana.
Tropical Metabolism Research Unit
Article Title
Neural tube defects in Jamaica following Hurricane Gilbert
Medium Designator
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Connective Phrase
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Journal Title
American Journal of Public Health
Translated Title
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Reprint Status
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Date of Publication
1994
Volume ID
84
Issue ID
3
Page(s)
473-6
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
An increased incidence of obvious live-birth neural tube defects (i.e., spina bifida cystica and encephalocele) occurred in Jamaica 11 to 18 months after Hurricane Gilbert. The conceptions of the affected babies coincided with a rise in megaloblastic change in sickle cell patients, suggesting a wide-spread drop in dietary folate intake. A detailed history was taken from each of the 17 affected mothers (case subjects) and 51 unaffected mothers (matched control subjects). The case subjects reported a significantly lower mean intake of dietary folate in the periconceptional period (154 micograms/day) than did the control subjects (254 micrograms/day). The temporary increase in neural tube defects was associated with a dietary level of folate that fails to protect against neural tube defects under natural conditions.....
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Keywords
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