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Publication Type
Journal Article
Author, Analytic
Forrester, Terrence E.; Badaloo, Asha V.; Persaud, Chandarika; Jackson, Alan A.
Author Affiliation, Ana.
Tropical Metabolism Research Unit
Article Title
Urea production and salvage during pregnancy in normal Jamaica women
Medium Designator
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Connective Phrase
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Journal Title
American Journal of Clinical Nutrition
Translated Title
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Reprint Status
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Date of Publication
1994
Volume ID
60
Issue ID
3
Page(s)
341-6
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
The pattern of aggregated nitrogen demand during pregnancy and the fetal and maternal components are unclear. Excess demand enhances efficiency of nitrogen utilization. Urea salvage contributes to enhanced efficiency. Dietary protein intake, urea production, and salvage of urea nitrogen were measured in eight nonpregnant control subjects, and trimesterly in nine pregnant women. Production was measured after prime-intermittent intravenous doses of [15N15N]-urea by dilution of label in urinary urea. Dietary protein intake was greater in trimester 1 than in nonpregnant women (167 36 vs 224 60 mg N.kg-1.d-1), and increased further in trimester 2 (266 59 mg N.kg-1.d-1). Urea production was not higher during pregnancy. Despite higher protein intake urea salvage was higer in pregnancy (40 24 nonpregnant vs 77 23, 61 31, and 51 12 mg N.kg-1.d-1). Therefore, the demand-supply gap for nitrogen was greatest early in pregnancy when fetoplacental growth is slowest, and implies heightened maternal demand.....
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Keywords
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