Wierenga, Klaas J. ; Pattison, John R.; Brink, Nicola; Griffiths, Meryl; Miller, Maolynne E.; Shah, Dipak J.; Williams, Winston; Serjeant, Beryl E.; Serjeant, Graham R.
Author Affiliation, Ana.
Medical Research Council Laboratories (Sickle Cell); Obstetrics, Gynaecology and Child Health; Pathology; Medicine
Glomerulonephritis after human parvovirus infection in homozygous sickle-cell disease.
Date of Publication
Glomerulonephritis with proteinuria of sufficient degree to manifest the nephrotic syndrome followed aplastic crises induced by human parvovirus (B19) in seven patients with homozygous sickle-cell disease, within 7 days in five patients and 6-7 weeks in two. Segmental proliferative glomerulonephritis was found in all four patients who underwent acute renal biopsies and focal segmental glomerulosclerosis was found in the fifth patient who had a biopsy 4 months later. One patient recovered completely, one died in chronic renal failure after 3 months, and the others had impaired creatinine clearance, four with continuing proteinuria.....