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Publication Type
Journal Article
Author, Analytic
Singhal, Atul; Thomas, Peter W.; Kearney, Tara; Venugopal, Sivarajan; Serjeant, Graham R.
Author Affiliation, Ana.
Medical Research Council Laboratories (Sickle Cell); Surgery, Radiology, Anaesthesia and Intensive Care
Article Title
Acceleration in linear growth after splenectomy for hypersplenism in homozygous sickle cell disease.
Medium Designator
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Connective Phrase
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Journal Title
Archives of Disease in Childhood
Translated Title
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Reprint Status
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Date of Publication
1995
Volume ID
72
Issue ID
3
Page(s)
227-229
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
Chronic hypersplenism in homozygous sickle cell (SS) disease markedly increases haemolysis and the resulting erythropoietic expansion is likely to have a high metabolic cost. Splenectomy for hypersplenism in SS disease is followed by highly significant changes in haematological indices and an increase in height, but not weight velocity. This pattern is similar to that observed in the trichuris dysentery syndrome after treatment, and differs from the increase in both height and weight velocity that follow nutritional supplementation of severely malnourished children. It is postulated that accelerated linear growth after the reduction in erythropoietic stress may implicate a specific nutrient deficiency in hypersplenic children with SS .....
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Keywords
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