Szentpály, L.V.,; Parkanyi, C.; Yuan, H.; Martin-Montez, M.; Tsai, K.M.; Aung, T.; Essoussi, H.T.
Author Affiliation, Ana.
Chemistry; Faculty of Pure and Applied Sciences
Flexible and rigid chain-linked bis-pyridmidine and bis-purine deravatices as potential intercalating agents
Advances in chemistry and molecular biology of cancer research
Place of Publication
Springer, New York
Date of Publication
Series Editor Role
Series Volume Identification
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Various types of organic compounds can bind to DNA by intercalation and thus exhibit anticancer, antiviral, or antiparasitic activity. Some of the interesting novel types of bifunctional intercalators are pyrimidine or purine bases or their analogs with a flexible or rigid chain providing a bridge between two such pyrimidine or purine units. The compounds with a flexible chain are represented by a series of polymethylene chain-bridged (with a varying number of methylene groups in the chain) subsituted bis-6-chloropyrimidines, bis-6-chloropurines, and bis-6-chloropurines with -pC6H4, CH2, -p-C6H4- and -p-C6H4, O. p-C6H4bridges. The synthesis, spectral data, and other physical properties of the new compounds will be discussed. The compounds are expected to be biologically active....