Sadler-McKnight, N.,; Jacobs, Helen M.
Author Affiliation, Ana.
Chemistry; Faculty of Pure and Applied Sciences
Application of the Folin-Ciocalteau reagent to the determination of salbutamol in pharmaceutical preparations
Date of Publication
A method for the determination of salbutamol in both tablets and syrups is described. It utilizes the reduction of the Folin-Ciocalteau reagent by the phenolic group, monitoring the absorbance of the resulting comples at 760 nm. Results obtained are linear over the range 0-6 mg ml-1 salbutamol. Coloring material was removed by anion exchange chromatography prior to analysis and there was no interference from sucrose, neutral flavourings or the common preservative sodium benzoate. This method appears suitable as a general assay for salbutamol....