Barrett-Adams, Dawn M.Y.,; Kahwa, Ishenkumba A.; Williams, David J.
Author Affiliation, Ana.
Chemistry; Faculty of Pure and Applied Sciences
Formylation versus alkylation of secondary amines in DMF
Acta Crystallographica. Section C
Date of Publication
2,2' -(Formamidedi-1,2 -ethanediyl)bis[1 H-isoindole-1,3-(2H)-dione] (1), C21H17N3O5, is a product of a slow formylation reaction between refluxing DMF and 2,2'- (iminodi-1,2-ethanediyl)bis[1 H-isoindole-1,3(2H)-dione] (DPDA) which appears to be more efficient than the competing base-promoted alkylation with tris(chloroethyl) amine. The molecules adopt a folded conformation and pack efficiently to form sheets (in the a and c directions) having a 'W in W' and 'M in M' motif running along the c direction....