Wilson, Wendell A.,; Morgan, Owen St. C; Barton, Everard N; Smikle, Monica ; Hanchard, Barrie; Blattner, William A; Doggett, Sarah; Gharavi, Azzudin E.
Author Affiliation, Ana.
Medicine; Microbiology; Pathology
IGA antiphospholipid antibodies in HLTV-1-associated tropical spastic paraparesis
Date of Publication
A retrovirus human T cell lymphotropic virus type I (HTLV-I), is an essential but not a sufficient aetiological factor for tropical spastic paraparesis (TSP). Because some TSP patients have biological false positive tests for treponemal infections (BFP-STS), we used EISA to study BFP-STS and anticardiolipin antibodies in 42 Jamaican TSP patients. The data indicate that in TSP anticardiolipin antibodies accur in about 26 percent of patients, are associated with biological false positive treponemal serology, are relatively restricted to the IgA isotype and may be induced by HTLV-I or other non-treponemal infections....