Manns, Angela; Wilks, Rainford J.; Hanchard, Barrie; Morgan, Owen St. C.; Rudolph, Donna L.; Lal, Renu B.
Author Affiliation, Ana.
Viral specific humoral immune responses following transfusion-related transmission of human T cell lymphotropic virus type-I infection.
Date of Publication
The immunoglobulin (Ig) isotypes of antibodies to specific proteins of the human T cell lymphotropic virus type I (HTLV-I) were determined by Western blot analysis of serial specimens from six individuals who experienced HTLV-I seroconversion following blood transfusion; five remained asymptomatic carriers, while one developed HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) 32 weeks posttransfusion. The results indicate the appearance of HTLV-I-specific IgM that persists even after the primary infection and suggest that such response does not appear to provide an early marker of seroconversion. Further, it was found no evidence of isotypic prominence or restriction of the antibody response in recipients who remained asymptomatic compared to one who developed HAM/TS....