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Publication Type
Journal Article
Author, Analytic
La Grenade, Lois; Thomas, Peter W.; Serjeant, Graham R.
Author Affiliation, Ana.
Medicine; Medical Research Council Laboratories (Sickle Cell)
Article Title
A randomized controlled trial of Solcoseryl and DuoDerm in chronic sickle-cell ulcers.
Medium Designator
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Connective Phrase
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Journal Title
West Indian Medical Journal
Translated Title
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Reprint Status
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Date of Publication
1993
Volume ID
42
Issue ID
3
Page(s)
121-3
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
A randomized controlled trial of Solcoseryl, DuoDerm and conventional conservative therapy with Eusol has been performed in 32 patients with homozygous sickle-cell (SS) disease. After 12 weeks' baseline observation, patients were randomized to one of three therapies and monitored for a further 12 weeks. Of 44 ulcerated legs, 20 received control treatment, 12 Solcoseryl and 12 DuoDerm. DuoDerm was generally unacceptable, and two-thirds of the patients defaulted from this treatment. Solcoseryl increased ulcer healing compared to the controls but the difference was not significant. Solcoseryl was well tolerated and may have a role in the treatment of chronic leg ulcers of sickle-cell disease....
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Keywords
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