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Publication Type
Journal Article
Author, Analytic
La Grenade, Lois; Sonoda, Shunro; Miller, Windell; Pate, Ernest J.; Rodgers Johnson, Pamela E. B.; Hanchard, Barrie; Cranston, Beverley; Fujiyoshi, Toshinobu; Yashiki, Shinji; Blank, Michelle; Gibbs, Clarence J.; Manns, Angela
Author Affiliation, Ana.
Medicine; Pathology
Article Title
HLA DRBI *DQB1* haplotype in HTLV-I-associated familial infective dermatitis may predict development of HTLV-I-associated myelopathy/tropical spastic paraparesis.
Medium Designator
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Connective Phrase
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Journal Title
American Journal of Medical Genetics
Translated Title
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Reprint Status
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Date of Publication
1996
Volume ID
61
Issue ID
1
Page(s)
37-41
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
A possible causal association between infective dematitis and HTLV-I infection was reported familial infective dematitis (ID) occurring in a 26-year-old mother and her 9-year-old son. The mother was first diagnosed with ID in 1969 at the age of 2 years in the Dermatology Unit at the University Hospital of the West indies (U.H.W.I.) in Jamaica. The elder of her 2 sons was diagnosed with ID at the age of 3 years, also at U.H.W.I. Both mother and son are HTLV-I-seropositive. A second, younger son, currently age 2 years, is also HTLV-I-seropositive, but without clinical evidence of ID. Major hitocompatibility complex (MHC), class II, human leucocyte antigen (HLA) genotyping documented a shared class II haplotype, DRB*DQBI* (1101-0301), in the mother and her 2 sons. The presence of this haplotype in these familial ID cases with clinical signs of HAM/TSP may have contributed to their risk for development of HAM/TSP. The unaffected, HTLV-I seropositive younger son requires close clinical follow-up....
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Keywords
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