Parshad, Omkar; Young, Lauriann E.; Young, Ronald E.
Author Affiliation, Ana.
Department of Basic Medical Sciences
Medicinal plants containing sedative activity with special reference to neem (Azadirachta indica, A Juss)
Wray, Samuel R.; Hernandez, N.; Parshad, Omkar
Brain, function, behaviour, drugs and disease : Neurosciences in the Caribbean
Place of Publication
Medical and Scientific Development Trust and Caribbean Brain Research Organization
Date of Publication
Series Editor Role
Series Volume Identification
Series Issue Identification
With the growing focus on alternative methods of health-care has come a new craze to treat everything, from losing weight to staving off the AIDS virus, with the use of herbs and other natural plants. Consumers in the United States of America spend some US$6 billlion annually on nutritional supplements, herbs, seeds, pollen and oils and the market continues to grow by 29% every year. Most useful sedatives and central nervous system (CNS) depressant drugs available today are the products of plants and herbs. Neem is one such unique plant with numerous medicinal properties. Currently, there has been a spurt in the production of low-cost commercial brands of products based on neem components. For example, a number of new toothpastes, washing soaps and anti-inflammatory compounds are now available. In the present study, the adminstration of a crude steroidal neem extract clearly demonstrated significant decreases both in the spontaneous motor activity (SMA) and amplitude of the peak twitch force, indicating a tranquillizing effect on rats. This depression of the SMA may be due to an effect of neem on the CNS and/or muscle strength but not on the peripherial nerve conduction. Although, this is a preliminary study and needs further expansion, it is suggested that neem could be a low cost source of an effective sedative in the future.....