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Publication Type
Journal Article
Author, Analytic
Kahwa, Eulalia ; Sargeant, Lincoln A.; McFarlane-Anderson, Norma ; Smikle, Monica ; Forrester, Terrence E.; Wilks, Rainford J.
Author Affiliation, Ana.
Department of Advanced Nursing Education
Article Title
Anticardiolipin antibodies and risk of thromboembolic disease in young Jamaican women
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Journal of Cardiovascular Risk
Translated Title
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Reprint Status
n/a
Date of Publication
2001
Volume ID
8
Issue ID
6
Page(s)
349-54
Language
eng
Connective Phrase
n/a
Location/URL
n/a
ISSN
1350-6277
Notes
n/a
Abstract
Anticardiolipin antibodies (aCL) are a heterogeneous group of antiphospholipid antibodies that are associated with arterial and venous thrombosis. We measured aCL in women, aged 15-49 years, to determine if they are an independent risk factor for thromboembolic disease. Case--control study . Fifty cases were studied including venous thromboembolism (n=29), stroke and myocardial infarction (n=21), along with 148 age-matched controls. Serum samples were assayed for aCL and anti-beta2 glycoprotein 1 antibodies using the enzyme-linked immunosorbent assay (ELISA). Information on other risk factors was obtained by a standardized questionnaire. aCL were present in 16/50 (32%) of cases compared with 25/148 (17%) of controls (P[?]=[?]0.02). Unadjusted odds ratio (OR) and 95% confidence interval (95% CI) for thromboembolic disease associated with aCL was 2.32 (1.10-- 4.87). Other risk factors were hypertension, 2.93 (1.20--7.17) and a history of other heart diseases, 12.78 (1.32--123.60). Adjustment for hypertension, diabetes, oral contraceptive use, smoking, alcohol use, varicose veins, a family history of cardiovascular disease and a history of other heart diseases yielded OR (95%CI) 2.99 (1.32--6.80). beta2 glycoprotein 1-dependent aCL were also an independent risk factor, OR 4.56 (1.76--17.83). Subgroup analysis was carried out separately for cases of MI and stroke and for venous thrombosis. Adjusted OR (95% CI) associated with aCL in cases of MI and stroke was 1.76 (0.46--6.73) and 3.32 (1.15--9.54) for venous thromboembolism. aCL are a risk factor for thromboembolic disease in young Jamaican women. They confer a strong independent risk for venous thromboembolism.....
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