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Publication Type
Journal Article
Author, Analytic
Smikle, Monica ; Wright-Pascoe, Rosemarie A.; Barton, Everard N.; Dowe, Gwendolyn; Gilbert, David T.; Choo-Kang, Eric G.; Morgan, Owen St. C.
Author Affiliation, Ana.
Department of Microbiology
Article Title
Autoantibodies, human T lymphotropic virus type 1 and type 1 diabetes mellitus in Jamaicans
Medium Designator
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Connective Phrase
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Journal Title
West Indian Medical Journal
Translated Title
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Reprint Status
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Date of Publication
2002
Volume ID
51
Issue ID
3
Page(s)
153-56
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
The clinical characteristics, autoantibody profiles and seroprevalence of human T lymphotropic virus type 1 (HTLV-1) were assessed in 30 Jamaican patients with type 1 diabetes mellitus. Two hundred and fifty-two blood donors and 108 patients with Graves' disease were included as controls for the HTLV-1 component of the study. The mean age of onset of diabetes mellitus was 20.5 9.2 years and the mean duration of diabetes mellitus was 10.5 6.1 years. The remarkable clinical data included an absence of other associated organ-specific autoimmune diseases, and clinical evidence and history of congenital rubella in one patient. Islet cell cytoplasmic antibodies (ICA) were absent but 17% (5/30) of the diabetic patients tested positive for glutamic acid decarboxylase (GAD) antibodies. No other organ-specific autoantibodies were detected but non-organ-specific autoantibodies were present in 9 (30%) of the sera of diabetic patients. The seroprevalence of HTLV-1 in the patients with diabetes mellitus was significantly higher than that in the healthy controls (17% (5/30) versus 4% (11/252), p = 0.05). Autoantibodies were found in the sera of 4/5 (80%) of the diabetic patients who were positive for HTLV-1. None of the patients with onset of diabetes mellitus below age 15 years was HTLV-1 positive. The likely polyaetiological nature of Type 1 diabetes mellitus in Jamaicans is being further investigated at the molecular level.....
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