McGrowder, Donovan A.; Ragoobirsingh, Dalip; Dasgupta Tara P
Author Affiliation, Ana.
Department of Basic Medical Sciences
Enchantment of the hyperglycaemic effect of S-nitrosoglutathione and s-nitroso-N-acetylpenicillamine by vitamin C in an animal model
Date of Publication
S-nitrosoglutathione (GSNO) and S-nitroso-N-acetlypenicillamine (SNAP) are two of the most common sources of nitric oxide (NO) in the biomedical field. Vitamin C has been known to accelerate the decomposition of GSNO and SNAP increasing the release and availability of NO which is cytotoxic at non-physiological concentrations. The study investigates any potential detrimental effect of vitamin C and GSNO, vitamin C and SNAP on glucose metabolism in normotensive and normoglycemic dogs.....