Manns, Angela; Miley, Wendell J.; Waters, D.; Hanchard, Barrie; Wharfe, Gillian H.; Cranston, Beverley; Williams, Elaine E.; Blattner, William A.
Author Affiliation, Ana.
Department of Pathology
Prognostic significance of quantitative viral markers in adult T-cell leukemia/lymphoma
Date of Publication
Adult T-cell leukemia/lymphoma (ATL) is a T-cell non-Hodgkin's lymphoma frequently associated with a leukemia phase and is caused by human T-cell lymphotropic virus type I (HTLV-I0. Development of ATL is preceded by high HTLV-1 antibody titers and characterized by monoclonal integration of proviral DNA in mononuclear cells in peripheral blood and/or lymph nodes. ATL has a broad clinical spectrum with several subtypes and corresponding differences in survival. The acute and lymphoma subtype have a prognosis of less than 1 year, while chronic and smoldering have longer survival and frequently precede the more severe types. Because proviral DNA level (proviral load) and antibody titers are important diagnostic markers, we evaluated their utility as predictors of survival in ATL.....