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Publication Type
Journal Article
Author, Analytic
Escoffery, Carlos T.; Shirley, Suzanne E.
Author Affiliation, Ana.
Department of Pathology
Article Title
Autopsy findings and causes of death in sickle cell disease
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Postgraduate Doctor
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2000
Volume ID
16
Issue ID
n/a
Page(s)
437-46
Language
n/a
Connective Phrase
n/a
Location/URL
n/a
ISSN
n/a
Notes
n/a
Abstract
Sickle cell disease (SCD) is the most common hereditary haematological disorder and is associated with increased morbidity and mortality. Many characteristic autopsy findings have been documented, some of which, though consistent, are not necessarily related to death (e.g. cardiomegaly, hepatomegaly, splenic atrophy and cholelithiasis). Common causes of death include the acute splenic sequestration and renal failure. A significant number of cases show no anatomical cause of death at autopsy. Thorough autopsies should be performed in as many SCD deaths as possible, and subtle causes of death such as septicaemia or biochemical abnormalities excluded appropriately.....
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