Escoffery, Carlos T.; Shirley, Suzanne E.
Author Affiliation, Ana.
Department of Pathology
Autopsy findings and causes of death in sickle cell disease
Date of Publication
Sickle cell disease (SCD) is the most common hereditary haematological disorder and is associated with increased morbidity and mortality. Many characteristic autopsy findings have been documented, some of which, though consistent, are not necessarily related to death (e.g. cardiomegaly, hepatomegaly, splenic atrophy and cholelithiasis). Common causes of death include the acute splenic sequestration and renal failure. A significant number of cases show no anatomical cause of death at autopsy. Thorough autopsies should be performed in as many SCD deaths as possible, and subtle causes of death such as septicaemia or biochemical abnormalities excluded appropriately.....