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Publication Type
Book Chapter
UWI Author(s)
Author, Analytic
Young, Lauriann E.
Author Affiliation, Ana.
Department of Basic Medical Sciences
Title, Analytic
Role of the mesolimbic system in the mediation of negative reinforcement: Implications for sensorimotor dysfunction
Medium Designator
n/a
Connective Phrase
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Author, Monographic
Wray, Samuel R.; Hernandez, N.; Parshad, Omkar
Author Role
Editors
Title, Monographic
Brain, function, behaviour, drugs and disease : Neurosciences in the Caribbean
Reprint Status
Refereed
Edition
n/a
Place of Publication
Kingston, Jamaica
Publisher Name
Medical and Scientific Development Trust and Caribbean Brain Research Organization
Date of Publication
2000
Volume ID
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Issue ID
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Page(s)
92-101
Series Editor
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Series Editor Role
n/a
Series Title
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Series Volume Identification
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Series Issue Identification
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Connective Phrase
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Location/URL
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Notes
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Abstract
The nucleus accumbens septi (NAS) is strategically placed to translate limbic information into the appropriate motor behaviour. It is accepted as a brain reward centre and has been implicated in the initiation of goal-directed behaviour. The present study was designed to investigate the role of the NAS in the mediation of avoidance behaviour following a negative reward paradigm. NAS-lesioned and sham-operated rats were post-operatively conditioned by subjecting them to a series of electric foot-shocks over a period of three minutes in a confirmed arm of a Y-maze. They were returned to the Y-maze 24 hours (trial 1) and 2 weeks (trial 2) following the aversive training to observe their explanatory and avoidance behaviours. Rats were also pre-operatively conditioned and their behaviour observed at trial 1 and post-operatively at trial 2. Pre-operatively shocked rats exhibited a significant decrease in exploration (p<0.01) and increased lesioned animals exhibited avoidance behaviour throughout both trials, without signs of habituation. The NAS thus, plays a necessary role in sensorimotor functions and appears to facilitate habituation and recovery from aversive learning experiences.....
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