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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Christie, Celia D.; Garrison, K.; Kiely, L.; Gupta, R.; Heubi, J.; Marchant, C.D.
Author Affiliation, Ana.
Department of Obstetrics, Gynaecology and Child Health
Article Title
A trial of a cellular pertusssis vaccine in hospital workers during the Cincinnati pertussis epidemic of 1993
Medium Designator
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Connective Phrase
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Journal Title
Clinical Infectious Disease
Translated Title
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Reprint Status
Refereed
Date of Publication
2001
Volume ID
33
Issue ID
7
Page(s)
997-1003
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
The safety and immunogenicity of pertussis (AP) vaccine in outbreak control was determined in a randomized, double-blind, controlled trial. Participants received AP vaccine (n=102), which contained 25 microg of pertussis toxoid (PT) and 3 microg of filamentous hemagglutinin (FHA), or licensed meningococcal cavvine (MN; n=97). Local reactions (pain or tenderness, redness, swelling and induration) and systemic reactions (fever, sleepiness or lethargy, and irritability) were similar among AP and MN vaccines. One month after AP vaccination, the geometric mean level of IgG anti-PT was 33.1 microg/mL, with 2-fold increases in 85% of patients and 4-fold increases in 73% of patients; for IgG anti-FHA, the respective values were 34.7 mocrog/mL, 92%, and 63%. After 6 months of follow-up, no serological evidence of pertussis was seen among symptomatic or asymptomatic subjects. however, recent evidence of Bordetella pertussis infection before immunization was shown. Thus, AP vaccine was safe and immunogenic in adults.....
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