Palmer, C. J.; Validum, L.; Lindo, John F.; Campa, A.; Validum, C.; Markler, M.; Cuadrado, R.R.; Ager, A.L.
Author Affiliation, Ana.
Department of Microbiology
Field evalution of the OptiMAL7 rapid malaria diagnostic test in tracking patient outcomes during anti-malaria therapy in Guyana
Transactions of the royal society of tropical medicine and hygiene
Date of Publication
The OptiMAL rapid test has been proven to be sensitive and specific in both clinical and field trials. This study evaluates the test for diagnosis of Plasmodium falciparum and P vivax infections in Guyana following anti-malarial therapy. Twelve patients identified using microscopy participated in the study and were treated with 600mg quinine every eight hours for five days followed by a single-day treatment on day 6 of Fansidar (1575mg) and primaquine (45mg) The patients were tested using blood films and OptiMAL on day 0, 3 and 5 post-treatment. There was 100% agreement between methods on day 0 and on day 3 there was 45% agreement with 5 patients remaining positive by OptiMAL who were blood film negative. On day 5 there was 83% agreement between the tests. The data showed that OptiMAL was an excellent diagnostic tool for evaluating malaria therapy in endemic areas.....