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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Maloney, Elizabeth M.; Morgan, Owen St.C; Widner, B.; Werner, E.; Fuchs, Dietmar
Author Affiliation, Ana.
Department of Medicine
Article Title
Central nervous system activation of the indoleamina 2,3, Diokygenase pathway IDO in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Medium Designator
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Connective Phrase
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Journal Title
Journal of Infectious Diseases
Translated Title
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Reprint Status
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Date of Publication
2000
Volume ID
181
Issue ID
6
Page(s)
2037-40
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
Human T cell lymphotropic virus type I (HTLV-I) is associated with a chronic neurologic disease called HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The potential mechanisms of HAM/TSP pathogenesis were assessed by examination of 2 pathways initiated by interferon-gamma, a predominant cytokine in HAM/TSP. Jamaican HAM/TSP patients (n=17) were compared with patients with other neurologic diseases (ONDs; n=13) with respect to cerebrospinal fluid levels of the following: neopterin; nitrite plus nitrate, a stable indicator of nitric oxide; and tryptophan and kynurenine, metabolites of the indoleamine-2,3-dioxygenase (IDO) pathway. HAM/TSP patients had significantly elevated levels of neopterin (P=.003) and kynurenine (P=.05) and a significantly decreased level of tryptophan (P=.003), compared with patients with ONDs. These results support immune activation within the central nervous system and activation of the IDO pathway. Thus, activation of the IDO pathway may play a role in HAM/TSP.....
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