Asemota,Helen N.; Grindley,P. B.; Omoruyi,Felix O.; Morrison,Errol Y.
Author Affiliation, Ana.
Hyperglycemia, hyperlipidemia and liver lipid metabolism in streptozotocin-induced diabetic rats fed organic extracts of yams or dasheen
Medical Science Research
Date of Publication
Streptozotocin-induced diabetic Wistar rats were fed supplements of extracts of yam (Dioscorea cayenensis) or dasheen (Colocasia esculenta) for four weeks during which the levels of blood glucose, lipids and liver transaminase activities were assessed. Enzymes involved in lipid metabolism in the liver were also assessed. Diabetic rats (Group B), diabetic rats fed yam extract (Group C), those fed dasheen extract (Group D) and those receiving linamarin (Group E) lost weight significantly despite non-significant differences in their food intake. Liver weights were significantly (P < 0.05) lower in these groups compared to healthy-control rats in Group A (P < 0.05). Groups C and D rats had significantly lower liver weights than Group B rats (P < 0.05). Group D rats had significantly lower blood glucose levels compared to Group B rats (P < 0.05). Feeding supplements of yam (Group C) or dasheen (Group D) extracts did not significantly reduce the blood total cholesterol level. The diabetic condition did not significantly affect the integrity of the liver as measured by alanine and aspartate transaminase activities. Feeding of yam or dasheen extract to diabetic rats significantly increased the activity of malic enzyme in the liver as compared to the unsupplemented diabetic group (Group B). Yam extract (Group C) and commercial linamarin supplements (Group E) significantly lowered the activity of glucose-6-phosphate dehydrogenase below levels seen in the normal healthy control (Group A). These observations show that the consumption of these staples may have some potential in lowering diabetic indices in Wistar rats, though there were adverse effects on the body, liver weight and feeding efficiency.....