View
Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Sargeant, Lincoln A. ; Khaw, K. T. ; Bingham, S. ; Day, N. E. ; Luben, R. N. ; Oakes, S. ; Welch, A. ; Wareham, N. J.
Author Affiliation, Ana.
Tropical Metabolism Research Unit
Article Title
Cigarette smoking and glycaemia: The EPIC-Norfolk Study. European Prospective Investigation into Cancer
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
International Journal of Epidemiology
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2001
Volume ID
30
Issue ID
3
Page(s)
547-54
Language
eng
Connective Phrase
n/a
Location/URL
n/a
ISSN
n/a
Notes
n/a
Abstract
Previous prospective studies have suggested that cigarette smoking may be associated with an increased risk of type 2 diabetes, but the possibility of confounding, particularly by dietary factors has not been fully examined. Conducted a cross-sectional analysis of the association between cigarette smoking and HbA(1C), a marker of long- term glucose homeostasis in 2704 men and 3385 women, aged 45--74 years who were recruited to a population-based study of diet and chronic disease. Twelve per cent of men and 11% of women reported being current smokers. Mean HbA(1C) was lowest in never smokers, intermediate in former smokers and highest in current smokers. There was a dose-response relationship between HbA(1C) levels and number of cigarettes smoked per day and a positive association with total smoking exposure as measured by pack-years. The unadjusted increase in HbA(1C) for 20 pack-years of smoking was 0.12% (95% CI : 0.09--0.16) in men and 0.12% (95% CI : 0.08--0.17) in women. After adjustment for possible confounders including dietary variables, the values were 0.08% (95% CI : 0.04--0.12) and 0.07% (95% CI : 0.02--0.12) for men and women, respectively. Mean HbA(1C) was inversely related to time since quitting smoking in men. These results add support to the hypothesis that smoking has long-term effects on glucose homeostasis, an association that cannot be explained by confounding by dietary factors as measured in this study.....
read more