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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Hisada, Michie ; Lal, Renu B.; Masciotra, Silvina ; Rudolph, Donna L.; Martin, Maureen P. ; Carrington, Mary ; Wilks, Rainford J.; Manns, Angela
Author Affiliation, Ana.
Tropical Metabolism Research Unit
Article Title
Chemokine receptor gene polymorphisms and risk of human T lymphotropic virus type I infection in Jamaica
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Journal of Infectious Diseases
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2002
Volume ID
185
Issue ID
9
Page(s)
1351-4
Language
eng
Connective Phrase
n/a
Location/URL
n/a
ISSN
0022-1899
Notes
n/a
Abstract
Polymorphisms of some chemokine receptor genes and their ligands are associated with susceptibility and progression of human immunodeficiency virus infection. This study assessed whether these variants are also responsible for susceptibility to infection with human T lymphotropic virus (HTLV) type I. Frequencies of CCR5-Delta 32, CCR2-64I, and SDF-1-3'A genotype among 116 HTLV-I-positive and 126 HTLV- I-negative persons of African descent in Jamaica were 1.0%, 14.9%, and 5.4%, respectively. The association of HTLV-I infection with the most common variant, CCR2-64I, was examined in 532 subjects. Thirteen (5.4%) of 241 HTLV-I-negative subjects were homozygous for CCR2-64I, versus 3 (1.0%) of 291 HTLV-I-positive subjects (P=.005). Among HTLV-I carriers, provirus load and antibody titer were not significantly different in persons with CCR2-+/64I or CCR2-+/+. These findings suggest that CCR2- 64I, or alleles in linkage disequilibrium with it, may affect the risk of HTLV-I infection in a recessive manner.....
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