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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Reid, Marvin E.; Jahoor, Farook
Author Affiliation, Ana.
Tropical Medicine Research Institute
Article Title
Glutathione in disease
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Current opinion in clinical nutrition and metabolic care
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2001
Volume ID
4
Issue ID
1
Page(s)
65-71
Language
n/a
Connective Phrase
n/a
Location/URL
n/a
ISSN
n/a
Notes
n/a
Abstract
Altered glutathione metabolism in association with increased oxidative stress has been implicated in the pathogenesis of many diseases. However, whether strategies aimed at restoring glutathione concentration and homeostasis are effective in ameliorating or modifying the natural history of these states is unknown. In this review we discuss the pathogenic role for altered glutathione metabolism in such diseases as protein energy malnutrition, seizures, Alzheimer's disease, Parkinson's disease, sickle cell anaemia, chronic diseases associated with ageing and the infected state. In addition, we discuss the efficacy of glutathione precursors in restoring glutathione homeostasis both in vitro and in vivo.....
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