View
Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Reid, Marvin E.; Jahoor, Farook
Author Affiliation, Ana.
Tropical Medicine Research Institute
Article Title
Methods for measuring glutathoine concentration and rate of synthesis
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Current opinion in clinical nutrition and metabolic care
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2000
Volume ID
3
Issue ID
5
Page(s)
385-90
Language
n/a
Connective Phrase
n/a
Location/URL
n/a
ISSN
n/a
Notes
n/a
Abstract
Altered gamma-glutamylcysteinylglycine homeostasis has been implicated in a wide variety of human diseases. The measurement of the rates of synthesis or loss of gamma-glutamylcysteinylglycine is necessary in order to make meaningful inferences about changes in gamma- glutamylcysteinylglycine concentration in these diseased states. In this review, we discuss methods for measuring gamma- glutamylcysteinylglycine concentration in biological samples as well as how improvements in the sensitivity of gas chromatography-mass spectrometric analyses have permitted the development of new and convenient stable isotope tracer methods for the in-vivo measurement of gamma-glutamylcysteinylglycine kinetics.....
read more