Buchanan, Greg O.; Williams, L.A. D.; Reese, Paul B.
Author Affiliation, Ana.
Biotransformation of cadinane sesquiterpenes by Beauveria bassiana ATCC 7159
Date of Publication
Incubation of cadina-4,10(15)-dien-3-one with Beauveria bassiana ATCC 7159 has resulted in the production of nine novel sesquiterpenes. These metabolites were identified as (4S)-cadin-10(15)-en-3-one, (4S)-3a-hydroxycadin-10(15)-ene, (4R)-3a-hydroxycadin-10(15)-ene, (4S)-3b-hydroxycadin-10(15)-ene, (4S)-3b-hydroxycadina-10(15),12(14)-diene, (4S)-13-hydroxycadin-10(15)-en-3-one, (4S)-12-hydroxycadin-10(15)-en-3-one, (4R)-3b,14-dihydroxycadin-10(15)-ene and 3a-hydroxycadina-4,10(15)-diene. The allylic alcohol 3a-hydroxycadina-4,10(15)-diene was also biotransformed to afford cadina-4,10(15)-dien-3-one, (4S)-cadin-10(15)-en-3-one and (4S)-12-hydroxycadin-10(15)-en-3-one. The insecticidal potential and phytotoxicity of the isolated metabolites have been evaluated.....