Chen, Avril R.; Reese, Paul B.
Author Affiliation, Ana.
Department of Chemistry
Biotransformation of terpenes from Stemodia maritima by Aspergillus niger ATCC 9142
Date of Publication
Incubation of temodin (1) in cultures of Aspergillus niger ATCC 9142 resulted in the production of 2a,3b,13-trihydroxy-stemodane (2), 2a,7b,13-trihydroxystemodane (3)and 2a,13,16b-trihydroxystemodane (4), while stemodinone (5) afforded 13,18-dihydroxystemodan-2-one (6) and 13,16b-dihydroxystemodan-2-one (7). Four novel metabolites were obtained from the bioconversion of stemarin (8) by the fungus, namely 18-hydroxystemaran-19-oic acid (9), 7b,18-dihydroxystemaran-19-oic acid (10), 7a,18,19-trihydroxystemarane (11) and 1b-hydroxystemaran-19-oic acid (12). 19-N,N-Dimethylcarbamoxy-13-hydroxystemarane (13) was also transformed to afford 19-N,N-dimethylcarbamoxy-13,17x,18-trihydroxystemarane (14).....