Collins, Dwight O.; Reese, Paul B.
Author Affiliation, Ana.
Department of Chemistry
Biotransformation of cadina-4,10(15)-dien-3-one and 3a-hydroxycadina-4,10(15)-diene by Curvularia lunata ATCC 12017
Date of Publication
Cadina-4,10(15)-dien-3-one (1) was metabolised by Curvularia lunata ATCC 12017 in two different growth media to give three metabolites, one of which, 12-hydroxycadina-4,10(15)-dien-3-one (4), was new. Incubation of 3a-hydroxycadina-4,10(15)-diene (2) with the fungus produced three new analogues, namely, (4S)-1a,3a-dihydroxycadin-10(15)-ene (5), 3a,14-dihydroxycadina-4,10(15)-diene (6) and 3a,12-dihydroxycadina-4,10(15)-diene (7).....