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Publication Type
Journal Article
Author, Analytic
Williams, L.A.D.; Mansingh, Ajai
Author Affiliation, Ana.
Life Sciences (Botany and Zoology); Faculty of Pure and Applied Sciences
Article Title
Insecticidally active triterpene from Artocarpus altilis Park
Medium Designator
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Connective Phrase
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Journal Title
Philippine Journal of Science
Translated Title
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Reprint Status
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Date of Publication
1995
Volume ID
124
Issue ID
4
Page(s)
345-357
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
Insecticidal activity directed isolation studies using adult Cylas formicarius (Summer) as the test organism revealed that one of the active compounds present in the non-polar extract of Artocarpus altilis Park leaves is a pentacyclic triterpene with unsaturation at the 12-13 position. The toxicity of the crude extract was reduced with each fractionation step. Thus, the order of the 48 hr LC50 (mg/g body wt.) doses for the crude ethanol extract and its hexane, methanol and ethyl acetate fractions and compounds was: 3.9 (crude extract) > 5.5 (hexane fraction) > 7.8 (methanol fraction)> 11.5 (triterpene). The ethyl acetate fraction was inactive i.e. > 10.0 mg/g dose inflicted only 20% mortality. The LC50 value derived for the triterpene when administered in 1.0% (v/v) dimethyl sulfoxide in acetone was 1.9 mg/g. This represents a 6-fold increase in the toxicity of the triterpene.....
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Keywords
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