Robinson, Ralph, D.; Lindo, John F; Neva, F. A.; Gam, A. A.; Vogel, Peter, A; Terry, S. I.; Cooper, Edward S.
Author Affiliation, Ana.
Life Sciences (Botany and Zoology); Faculty of Pure and Applied Sciences
Immunoepidemiologic studies of Strongyloides stercoralis and human T lymphotropic virus type I infections in Jamaica.
Journal of Infectious Diseases
Date of Publication
Epidemiologic investigations of Strongyloides stercoralis and human T lymphotropic virus type I (HTLV-I) infections were conducted. Of 312 persons contacted, 209 (67 %) provided blood and stool samples. Prevalence of S. stercoralis and HTLV-I antibodies was 26.8 % and 8.1 % (n = 198), respectively, and S. stercoralis larvae were detected in 4 %. HTLV-I antibodies were significantly more common in persons positive for S. stercoralis larvae (10 [58.8 %] of 17) compared with seropositive larva-negative (4 [8.9 %] of 45) or seronegative persons (9 [6.2 %] of145) (p< .002). IgE levels increased with age in S. stercoralis-seropositive persons who were HTLV-I negative (p<.002). However, there was an age-related depression of serum IgE in HTLV-I-positive persons (p< .003) that was sufficient to annul the IgE level-raising effect of S stercoralis seropositivity. The data provide evidence that HTLV-I infection is associated with increased frequency of larvae in the stool of S. stercoralis-infected persons and suggest that the mechanism may involve suppression of the IgE response.....