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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Martin, G.D.A.; Reynolds, Williams F.; Reese, Paul B.
Author Affiliation, Ana.
Department of Chemistry
Article Title
Investigation of the importance of the C-2 and C-13 oxygen functions in the transformation of stemodin analogues by Rhizopus oryzae ATCC 11145
Medium Designator
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Connective Phrase
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Journal Title
Phytochemistry
Translated Title
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Reprint Status
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Date of Publication
2004
Volume ID
65
Issue ID
15
Page(s)
2211-2217
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
Incubation of 2alpha,13(R)-dihydroxystemodane (3) with Rhizopus oryzae ATCC 11145 gave 2alpha,7beta,13(R)-trihydroxystemodane (11) while biotransformation of 13(R)-hydroxystemodan-2-one (5) yielded 6alpha,13(R)-dihydroxystemodan-2-one (12) and 7beta,13(R)-dihydroxystemodan-2-one (13). Bioconversion of 2beta,13(R)-dihydroxystemodane (7) with Rhizopus afforded 2beta,7,13(R)-trihydroxystemodane (14). The results complement data from our previous work and provide more information about the effect of functional groups of stemodane substrates on the site of hydroxylation.....
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