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Publication Type
Conference Proceedings
Author, Analytic
Powell, Melissa P.; Wheatley, Andrew O.; Tennant, Paula F.; Omoruyi, Felix O.; Asemota, Helen N.; Gonsalves, Dennis; Ahmad, Mohammed H.
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Author Affiliation
Department of Basic Medical Sciences
Paper/Section Title
Rat Intestinal Transport Enzymes: Effects of Consumption of Transgenic Papaya (Carica papaya L.)
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Proceedings Title
Human Proteome Organisation (HUPO) Second Annual and International Union of Biochemistry and Molecular Biology (IUBMB) Nineteenth World Congress
Date of Meeting
October 8-11, 2003
Place of Meeting
Montreal, Canada
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Date of Publication
2003
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Abstract
Genetically modified papaya was engineered using microprojectile bombardments to transform papaya tissue cultured materials with the coat protein gene of a local strain of the Papaya ringspot virus (PRSV) isolate from Jamaica, sandwiched between the neomycin phosphotransferase type II (NPTII) and the -glucoronidase (GUS) genes in the binary vector pGA482GG. As with any new technology, public discussion has arisen concerning the safety and advantages of genetically modified crop plants and plant products. In light of public concerns on the consumption of transgene proteins, this study was designed to assess the effects of subchronic dietary consumption of this transgenic papaya on the rat intestinal enzymes Ca2, Mg2 and Na / K ATPases. These are membrane bound enzymes that are responsible for maintaining the intracellular concentrations of many anions, cations and small organic compounds. It is therefore important to analyze the activity of these enzymes to ensure that vital transport functions are not compromised by the consumption of this transgenic papaya. Our results showed no significant differences in the activities of these enzymes among the test groups compared to the control group that consumed regular rodent diet. It is therefore possible to conclude that consumption of genetically modified papaya may not alter the activities of these transport enzymes.....
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