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Publication Type
Conference Proceedings
Author, Analytic
McKoy, Marsha-Lyn G.; Omoruyi, Felix O.; Asemota, Helen N.; Simon, Oswald R.
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Author Affiliation
Department of Basic Medical Sciences
Paper/Section Title
Evaluation of toxicological effects of a sapogenin-rich yam (Dioscorea sp.) preparation with potential for treating hypercholesterolemia
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Proceedings Title
Experimental Biology 2004: Meeting Abstracts
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Date of Publication
2004
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Abstract
Recently we reported that a sapogenin-rich 'preparation' from a Jamaican yam variety (Dioscorea sp.) had anti-lipaemic effects as it inhibited cholesterol-induced increases in plasma total cholesterol, LDL + VLDL-cholesterol and triglyceride levels in rats. The focus of the present investigation is on the toxicological effects of this 'yam preparation'. Hypercholesterolemia was induced by feeding rats (n = 8) cholesterol, 4% of the diet, over a 6-week period. Administration of the 'yam preparation', 5% of the diet, over the following 6 weeks reversed hypercholesterolemic effects. There was no evidence of ulceration of the stomach or other gross toxicological effects after 6 weeks of daily administration of the 'yam preparation'. Additionally, histological studies of liver and kidney samples and determination of liver and kidney transaminase activities did not indicate damage caused by the course of treatment. There was no sign of acute toxicity following administration of high doses. As the 'yam preparation' reduced plasma lipid levels and blood pressure in hypercholesterolemia without causing apparent toxicity, we conclude that its administration may be an effective and safe alternative in managing hypercholesterolemia.....
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