McAnuff, Marie; Omoruyi, Felix. O.; Gardener, Michael T.; Asemota, Helen N.; Morrison, Errol Y.
Author Affiliation, Ana.
Departemnt of Basic Medical Sciences
Alterations in Intestinal Morphology of Streptozotocin-induced Diabetid rats Fed Jamaican Bitter Yam (Diascorea polygonoides) Sapogenin Extract
Date of Publication
In this study, the effect of yam steroidal sapogenin extract on intestinal morphology in streptozotocin-induced diabetic rats was examined. Diabetic male Wistar rats (n = 32) were fed diets supplemented with 1% bitter yam steroidal sapogenin extract or commercial diosgenin for three weeks. The effect on intestinal morphology was assessed. The induction of diabetes significantly increased villus length and crypt depth compared to the normal group. Supplementation of the diet with sapogenin extract or commercial diosgenin significantly increased villus width compared to the diabetic controls. The dietary supplements also significantly decreased crypt depth towards that of the normal controls. This study shows that the feeding of bitter yam steroidal sapogenin extract to diabetic rats may result in alterations in the intestinal morphology.....