McAnuff, Marie; Omoruyi, Felix O.; Morrison, Errol Y. ; Asemota, Helen, N.
Author Affiliation, Ana.
Department of Basic Medical Sciences
Plasma and Liver Lipid Distributions in Streptozotocin - induced Diabetic Rats Fed Sapogenin Extract of the Jamaican Bitter Yam ( Dioscorea Polygonoides )
Date of Publication
Bitter yam (Dioscorea polygonoides) steroidal sapogenin extract and commercial diosgenin were administered to diabetic rats for 21 days. Plasma glucose and lipids were assessed. Liver lipid distributions were also determined. The two dietary supplements fed to diabetic rats resulted in significant decreased body weight gain. The test diets significantly lowered plasma glucose and total cholesterol. Sapogenin extract supplement significantly lowered plasma total triglycerides. Plasma and liver VLDL+LDL-cholesterol were significantly reduced while the HDL fraction was increased in diabetic rats fed the test supplements. These results showed that the consumption of the two supplements may be useful in the management of hypercholesterolemia often associated with diabetes. (AU)....