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Publication Type
Journal Article
Author, Analytic
Barrett, K.; McGrowder, Donovan A.; Brown, Paul D.; Ragoobirsingh, Dalip
Author Affiliation, Ana.
Departement of Basic Medical Sciences
Article Title
Insulin-Stimulated Glucose Uptake is Inhibited in Adipocytes [Abstract]
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
West Indian Medical Journal
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2004
Volume ID
53
Issue ID
Suppl. 1
Page(s)
42
Language
n/a
Connective Phrase
n/a
Location/URL
n/a
ISSN
0043-3144
Notes
n/a
Abstract
Objective: To investigate the role of nitric axide on insulin-related D-glucose-[1-3H(N)] uptake in adipo-cytes from streptozotocin-treated diabetic rats. Method: Sixteen adult Wistar rats weighing between 120-300 g were divided into two groups consisting of eight rats. The drug-treated group was injected with 65 mg/kg body weight streptozotocin (STZ) in conjunction with 180 mg/kg body weight nicotinamide, to include Type 2 diabetes mellitus. Control rats were injected with saline. After four weeks, an oral glucose tolerance test was performed and control and diabetic rats sacrificed. Blood was collected for insulin determination and D-glucose-[1-3H(N)] uptake into adipocytes inthe presence and absence of insulin measured. Conclusion: The results of the study indicate that the NO-releasing drug has direct inhibitory effect on insulin-stimulated glucose uptake in adipocytes and may thereby have a role in the aetiology of Type 2 diabetes melitus.....
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