O'Connor, A.; McFarlane-Anderson, Norma; Duff, Edith M. ; Wright-Pascoe, Rosemarie A.
Author Affiliation, Ana.
Department of Basic Mecical Sciences
Oxidative Stress in Adults with Diabetes Mellitus
West Indian Medical Journal
Date of Publication
53 Suppl. 1
Background: Excess oxidative stress has been suggested as a potential mechanism for the increased vascular damasge in diabetes mellitus. Possible sources of oxidative stress in diabetes mellitus include altered carbohydrate and lipid metabolism, decreased levels of antioxidant defenses and most importantly, increased generation of reactive oxygenspecies as a result of the metabolic derangements, lipid peroxidation and glycation. Investigation of oxidative stress as a correltae of glycaemic control is therefore useful in diabetes management. Growing evidence suggests isoprostane as a reliable and sensitive marker of in vivo lipid peroxidation that can easily be measured. (AU)....