Moodie-Henry, B.; West, Manley E.; Gossell-Williams, Maxine D.
Author Affiliation, Ana.
Department of Basic Medical Sciences
Investigation of the pharmacological activities of aqueous Alkaloidal Extract of Borreria Verticillata on the Cardiovascular and Uterine Systems
West Indian Medical Journal
Date of Publication
Objective: Decoctions of Borreria verticillata are used in folklore medicine to lower blood pressure and as an abortificient. The objective is to investigate if there is any scientific rationale to these folkloric uses. Methods: Aqueous extracts of Borreria verticillata (tested positive for alkaloids using Drangedorff's reagent) were given intravenously to Sprague-Dawley rats of either gender weighing between 250 g to 350 g. Blood pressure measurements were recorded usng a pressure transducer attached to a 79 E grass polygraph. the aqueous extract (alkaloidal) was also tested for activity on isolated rat uterus (both pregnant and non-pregnant) maintained in De Jalon's solution in an organ bath. isometric tension was recorded using a force displacement transducer attached to a 79E grass polygraph. The effects of the extract were observed independently and in the presence of adrenalin and oxytocin.....